Since complex industry object has characteristic of non-linearity, uncertainty and time-change, this paper studied about application of self-regulation PID-Fuzzy controller for flume system. The properties of the basic fuzzy controllers can be improved through compiling S-function and subsystem that automatically corrects the quantizing factors Ke and Kc. The proportional, integral and derivative constant adjusted by new rule of fuzzy to adapt with the extreme condition of process. Fuzzy control applies language rule to describe controlling process and bases rule to modify the controlling arithmetic and parameter. The new algorithm performs in every condition and already tested in every extreme condition. The simulation result shows that the controller possesses virtues of self-adaptability and short adjusting time. It will realize production process control.