The casting process design and simulation of the volute of 65ZGB slurry pump were presented in this paper. The casting process design principle, process parameters, points of attention, and the simulation parameters were introduced. Huazhu CAE was used to simulate the casting process. The STL document used in Huazhu CAE was converted from the 3D moulding of the casting process using the Solidwork software. The simulation results and practical production showed that the casting process can reduce shrinkage defects of the casting.