The flow stress data of the workpiece are extremely crucial for the cutting simulation. The study shows how the input data affect the analytical predictions of cutting force and temperature. The Johnson-Cook material model is used to represent workpiece flow stress in the primary shear zone. A thermomechanical model of orthogonal cutting is proposed based on the main shear plane divides the primary shear zone into two unequal parts. Five different sets of workpiece material flow stress data used in the Johnson-Cook’s constitutive equation are chosen and make the sensitivity analysis for analytical model. Simulation results were compared to orthogonal cutting test data from the available literature, and find the effects of flow stress on analytical model was different from that for finite element model.