A novel 5-Degree of Freedom PCMM (parallel coordinate measuring machine) was proposed, and its motion control system was designed. Compared with the other structural PCMMs, the structure feature of proposed PCMM was described. Then its motion control system was designed with the modularized and open architecture. The controlled scheme of hardware, which based on PC, PMAC motion control card and the precision measuring probe, was developed. The software of the motion control system was written by Visual Basic6.0 language. Finally, the process of motion control for 4-UPS-UPU PCMM was proposed. The new method above for design of motion control system is simple and effective, and may be applied to other parallel machine.