Nanoparticles have been used with polymer to make composites having remarkable properties. An attempt was made in this direction, in order to enhance the mechanical and tribological properties of nanocomposites. In the paper, the polytetrafluroethylene (PTFE) polymer-based nanocomposites filled with serpentine (SPT) and reinforced with different nanoparticles such as nano-β-carborundum whisker (β-SiCw), nano-copper and nano-TiO2 were prepared by using cold briquetting and hot-press sintering technologies. Also, the mechanical performances of these nanocomposites were studied. The quasi-static tensile experiments and dynamic mechanical thermal analysis (DTMA) were carried out. The results obtained showed that the mechanical properties of these nanocomposites stronger depend on the variety of nanoparticle. Stress-displacement and stress relaxation curves indicate that theses composites are typical viscoelastic materials. These research findings are believed to be helpful for providing practical guide in applications.