There are many factors that affect the safety and reliability of large winding hoist’s cylinder shell structure，and most of them are of more or less randomness，But,in the reliability analysis of tube shell structure, For factors on the tube shell vary from degrees of structural failure. Therefore, It is of great significance to study the size of the various factors that affect the reliability of the tube shell structure. In this paper, the large winding hoist cylinder shell reliability sensitivity were calculated and analyzed using the latest achievements of reliability sensitivity calculation. The results show that，the mean square deviation of strength ( ) and stress ( ) are larger, the tube shell structure becomes more insecure, and the strength ( ) to tube failure rate of the shell structure is getting much larger than the stress ( ). The intensity ( ) on the tube shell is greater than stress ( ) on the impact of structural failure， respective proportion is 82.24% and 17.76%. we will strictly control the intensity’s change in designing, manufacturing and using of large winding hoist cylinder shell structure, and As far as possible to the direction of the large fluctuations; For the stress( ), will as far as possible so that the direction to small fluctuations. This theoretical research and practical calculation of the structure have a larger theoretical significance and practical value in studying hoist cylinder shell structure on design, manufacture and use.