The paper designed a multi-channel data acquisition system based on PXI 6281. It used DAQmx technology in LabVIEW for synchronous analog channel data acquisition. It realized multi-channel real-time data acquisition, processing, display and data auto-saving. Data acquisition system consists of three major modules: the pressure measurement module, the motor speed measurement modules and real-time temperature measurement module. It has advantage of short cycle of technological upgrading, development and low maintenance costs. It has some reference value for other data acquisitions.