The capability of structure resisting progressive collapse depends on controlling the dispersion of damage by uncommon agency in the part of the structure and to avoid the destruction just likes the Domino action. For the RC frame, when one column under the beams was broken, the key to avoid progressive collapse is whether the frame beams can bear the column’s load to produce a new way for transmitting the force or not. In this paper, the simulation analysis to a six-layer frame structure which designed by the concrete structural design codes is put up according to the four failure position of columns. The following conclusions are concluded: the damage in vertical region does not appear or appear very little because of a strong stiffness in joint between invalid column and beam. Structural collapse was resulted by the collapse stress from displacement transfering the other end of beam connected with columns.