This paper presents a novel compliant linear guided mechanism (CLGM) to replace traditional spring and translation joint to transfer motion and force with its advanced guiding characteristics. In view of the incompatible relationship between axial stiffness and transverse stiffness of CLGM, eight kinds of CLGMs were developed by using building block approach based on fixed-guided flexure beam. The finite element analysis (FEA) models of eight CLGMs were built to complete numerical analysis on the force-displacement in axis and off-axis direction with same geometric sizes. The FEA results show that the structure configuration of Type 2-Type 8 can achieve a larger axial travel, Type 2 and Type4 have the advanced guiding characteristic with higher ratio of axial/transverse stiffness. Analysis indicates that the building block approach is an efficient method to complete the conceptual synthesis of compliant mechanism and FEA is effective on the structure optimization for the required compliance and stiffness in axial and transverse direction.