Non-Structural road driving test is a key part of fatigue and durability tests for vehicles such as the construction machines and ATVs. Combining a theoretic road-tyre dynamic model with some real vehicle design parameters, the responses of the wheel axle under different non-structural road conditions were estimated conveniently. The responses can be taken as inputs for a virtual test-rig simulation, and the responses of every part on the test object are obtained separately. Fatigue life is predicted under the finite element circumstance, and the reliability and durability are concluded. Comparing with the real road-driving test, the virtual fatigue test method above can significantly reduce the test period. This method is used to predict the fatigue life of the rear axle-housing in construction machines, the accuracy of the method is verified by a corresponding real bench test.