In this paper, the main design parameters of seal structure for non-API pipe connection are studied. First, as the total contact pressure consists of the radial preload generated by interference fit and the radial pressure caused by gas pressure in pipe, the variation laws of their values changing with the sealing diameter are analyzed. The sealing diameter value which maximizes the total contact pressure can be obtained from the derivation formula for calculating the total contact pressure. Second, considering the yield condition of pipe connection under the internal and the external pressures, the minimum wall thickness of the seal structure is derived. Then the cone angle is calculated by the sealing length and the minimum wall thickness known. Finally, take the 7in casing connection for example, the main design parameters are calculated by the above analysis.