Copper has some excellent performances in anti-erosion and high thermal conductivity. It is applicable in many important fields. In the paper, two methods of preparing Ni-Cr alloy cladding layer on the surface of copper are proposed, including the spray welding and YAG pulse laser cladding .Then the Ni-Cr alloy layer prepared on the copper is investigated by optical microscopy, there is no hole and crack in the cladding layer. The experimental results show the coating is metallurgically bonded with the substrate. In comparison to the prepared cladding layers, the Ni-Cr cladding layer prepared by YAG pulse laser is the better, the size of copper is not restricted, and the copper substrate isn’t preheated.