To optimize injection molding warpage, this paper applies the uniform design of experiment method to search for the optimal injection molding processing parameters. The warpage. simulation analysis is accomplished by emplying Moldflow software. The melt temperature, mold temperature, injection time and packing pressure are regarded as processing parameters, and processing parameters are optimized through establishing a regression equation, and the optimization result and influence factors are analyzed. The results show that uniform design of experiment can reduce number of experiments used effectively and the quality of the product is greatly improved by the optimization method.