In mobile network, cell coverage analyses are vital to network optimization. The traditional check method is road testing by manpower which costs much time and resources. This paper presents a multiple factors analysis method of cell coverage, and designs the relevant system based on GIS platform. Based on a huge number of mobile measure data in OMC, this method derives a cell coverage analysis chart and identification of the problem cells by analyzing multiple factors such as signal level distribution, sample point distribution, category of interferences, neighborhood relationship, and azimuth ward and so on. The calculation and analysis results are presented in map based on GIS platform. This method and system are validated by a large number of actual datasets from an in-service GSM network.