Current management of road traffic safety is featured by lower efficiency and quality in China. The paper is intended to seek a possible solution for improving the management of road traffic safety by using the systems perspective of safety from Vision Zero for reference. The situation of the management of road traffic safety is described first. Compared with traditional ideas and epidemiology-based ideas on road traffic safety, the perspective is introduced. After that, it is used in analyzing the problems in current management of road traffic safety and looking for the countermeasures for them. Different from other studies in China, the paper highlights the introduction and application of the systems perspective of safety as the leading ideas in the field.