The structure of the centrifugal pump with splitting blades is complex, and the law of the internal flow is not fully grasped. Therefore Reverse Engineering (RE) and numerical simulations of Computational Fluid Dynamics (CFD) are adopted to study the centrifugal pumps with splitter blades. In this process, the law of velocity and pressure distribution of internal flow about the centrifugal pump with splitter blades is preliminary disclosed. In addition, performance prediction was carried out in centrifugal pumps. Comparing to the calculation curve and text characteristic curve, it’s obvious that simulation results are in good agreement with experimental results. The results verify the reliability and feasibility of the research method.