The feasibility of using piezoelectric smart devices to develop a smart material-structure system and thereby to prevent structure from earthquake is carried out in this study. The piezoelectric actuators are utilized to develop a smart friction damper with controllable parameters. The interaction of a smart material-structure system is analyzed through the numerical integral and iteration. The seismic mitigation of the dynamic responses of a workshop structure with the piezoelectric smart controllers is conducted through a proposed semi-active control strategy. It is observed that the structural seismic responses can be remarkably mitigated under the protection of the smart system..