Lithium titanate compound, Li4Ti5O12 was prepared by a solid state reaction. The raw material, the calcination time, the atmosphere of the reaction and other conditions were investigated. The crystal structure and the electrochemical performance of the synthesized materials were characterized by X-ray powder diffraction (XRD), laser particle-size distribution measurement (LSD), and electrochemical performance testing. The XRD patterns showed peaks attributable to Li4Ti5O12 phase for the sample prepared by LiOH•H2O, while there was impurity peak in the pattern of the sample prepared by Li2CO3. The precursor was sintered at various times of 12h and 24h at 800 °C. The galvanostatically charge and discharge tests show that the capacity and the cycle performance of the latter is obviously more excellent. The atmosphere of the reaction hasn't exerted a great influence on the performance of the material.