The finite element simulation is an engineering technology developed with the development of computer technologies, which is also an important development direction of structure design and analysis in the future. With the rapid development of computer software and hardware technologies, it is a tendency to perform the exquisite FE simulation analysis for structure by high performance computer (HPC). In this paper the exquisite FE simulation analysis of global model consisted of block elements and shell elements is performed by means of HPC based on Steel-concrete composite cable-stayed bridge. Moreover, the shrinkage and creep effect in the construction and post-construction period are considered. Besides effectively guiding the design, the high accurate analysis results indicate that it is practical to perform the refined FE simulation analysis by HPC.