Degeneracy problem is an inevitable result of sequential importance re-sampling (SIR) particle filter, and a mass of degenerated particles will influence the tracking ability of particle filter seriously. As a result, SIR particle filter based predication algorithm can’t predict system faults accurately. Artificial immune algorithm is characterized by a global ability to search for optimum, so it is introduced into the particle filter, named artificial immune particle filter (AIPF). Particles are regarded as antibodies in AIPF and particles with large weight aberrance and are cloned, and then the better particles are selected for states evaluation. A fault predication algorithm based on AIPF is proposed to improve the predication accuracy, and simulation results have demonstrated the feasibility of the proposed algorithm.