Measurement of wheel set wear was an important step for the safety of train running. High-speed acquisition and processing method for high resolution image of wheel set based on the hardware platform of DSP (digital signal processor) and PC was proposed. High-speed acquisition and processing was completed by PC and DSP unit separately. PC and DSP unit worked in parallel operational mode. Ethernet transport program based on TCP was designed for data exchange. Asynchronous reset pulse generation circuits were designed. High resolution images of wheel set were captured in 500fps and asynchronous reset mode. Resolution of images was 1280*1024. The experimental results showed that this method improved image processing speed effectively.