Indirect stabilization technology can make the optical seeker lower cost and more compact, but it will also decrease the system’s performance. In order to improve the line-of-sight (LOS) stabilization precision, the indirect stabilized seeker’s model and loop control algorithm must be deeply studied. In this paper, the dynamic model of LOS coordinate frame is created according to the working principle of indirect stabilization system; A new no-angle-error control scheme was proposed. For severse disturbance environment, a feedforward torque compensation control algorithm was proposed based on disturbance torque estimation. The simulation and experiment results show that the proposed control approach can make the system tracking the instruction angular rate quickly and exactly, and also have the strong disturbance resistance ability. The study result will have great significance to the indirect stabilization technology’s theory study and engineering application.