Good performance of driving power supply is the key to achieve high-precision positioning of the piezoelectric ceramic. In this paper, mainly from the expansion of power channel, lower ripple and interference, reducing the volume and temperature control of amplifier such aspects, developed PZT multi-channel power supply based on PA93 power amplifier, and completed the corresponding experiments of the calibration characteristics. By testing, the output voltage of eight channels shows good linearity, the nonlinear error is less than 0.05％. the resolution is 6mv, the static ripple voltage is less than 9mV, the power bandwidth could be 5kHz, the continuous output current could be 1.5A, the voltage variation is less than 0.01％ after eight hours continuous working. The volume of power supply is only 280*260*120mm, the power supply could satisfy the requirements of PZT driving.