In this article we present an overview on two-person zero-sum games, which play a central role in the development of the theory of games. Two-person zero-sum games is a special class of game theory in which one player wins what the other player loses with only two players. It is difficult to solve 2-person matrix game with the order m×n(m≥3,n≥3). The aim of the article is to determine the method on how to solve a 2-person matrix game by linear programming function linprog() in matlab. With linear programming techniques in the Matlab software, we present effective method for solving large zero-sum games problems.