In this paper, based on the theoretical analysis and reasonable simplification, one-dimensional mathematical model is presented for the counter-current oxidation of ventilation air methane. The process of counter-current oxidation reaction is simulated by applying the computational fluid dynamics (CFD) software (Fluent), and the effect of the dominating working parameters (such as flow velocity and equivalence ratio and half cycle) are discussed on the temperature and rate of reaction within the counter-current oxidation reaction. The distribution of the temperature field and the reaction rate are simulated when half cycle is 30s, the equivalence ratio is 0.2 and the velocity 0.06 m/s, 0.1m/s and 0.2 m/s. The combustion characteristics are summarized for the device of counter-current oxidation reaction, and the effects of working parameters are analyzed on the burning characteristics. It is so important to increase the combustion efficiency and energy utilization.