Goods and shelves are closely and numerously put in the logistics center, so there are many hidden dangers. People’s life safety and property safety are threatened by fire. The key of putting out fire and evacuating people is to grasp the changes of the important parameters in the fire. In this paper the FDS (Fire Dynamic Simulator) software developed by the U. S. National Institute of Standards and Technology (NIST) is used to build a fire model and sets two fire scenarios to analyze the fire spreading process in logistics center. According to the numerical simulation results, reasonable suggestions are put forward in the end.