By the finite element analysis codes ABAQUS and the function of RESTART, a sequential coupling calculating program for creep based on welding residual stress has been developed by establishing the model of temperature field, residual field and creep analysis. The welding residual stress and creep of welded joint for Cr5Mo furnace tubes was simulated by the program. This method established the basis for calculating the effects of welding residual stress on the creep of welded joint. A creep comparison between the welded joint tubes with welding residual stress and with internal pressure was made in the paper. The results show that although the residual stress is greatly decreased due to the creep relaxation behavior at high temperature, the initial welding residual stress has a great influence on the tube creep. The research results provide a reference for strength design of high temperature components.