Tapered Roller Bearing can take huge radial load or two way axial load. It is widely used in over loading, steel rolling, metallurgy, etc. In this paper, according to the structural properties of Tapered Roller Bearing, we established an mathematical model to optimize the design of Tapered Roller Bearing. Based on the comparison of the result from our design and the traditional design of the Four Column Tapered Roller Bearing 3811/750/HC, the dynamic load increases 22% and the working life expectancy increases 85% by using our design. This fully shows the economical meaning of the optimization design, and it provides a practical method for the optimization design in future.