Road traffic accident forecast is a complex stochastic process. Based on the statistics of road traffic accident, Grey Model (1, 1)( short for GM(1, 1)) was applied to forecast the future number of road traffic accident in this paper. GM(1, 1) was established according to the time-series. GM(1, 1) is usually applied for such stochastic unconfirmed problem as road traffic accident forecast. Base on MATLAB software, the forecast value of road traffic accident was given. The precision of the test results show that the model is accurate and the forecast results are reliable.