The model of heat transfer tube was established to obtain the distribution of velocity field, temperature field and pressure field with the aid of the computational fluid dynamics (CFD). The effect of the twisted-tape on the distribution of all fields in the tube was discussed. Seven pipes were constructed with different torsion to examine the torsion ζ and Re effect on the heat transfer and flow resistance. Nusselt number Nu and the ratio of pressure difference △P /△ P0 in the tube with and without twisted-tape inserted was used to measure the heat transfer and flow resistance. The results show that the twisted-tape and large Re can enhance heat-transfer efficiency to some extent in same conditions; however it also leads to the loss of flow resistance. Structure optimization by changing the parameters and Re is what we should consider for further research.