The plastic deformation behavior of the and  Fe-35wt.%Cr alloy single crystals containing fine Cr-rich precipitates were investigated under uniaxial compression. The compressive flow behavior is slightly sensitive to the crystallographic orientation. These two oriented crystals exhibit a clear yield plateau in their compressive stress-strain curves, but the yield plateau of the  crystal is somewhat shorter than that of the crystal. As the compressive strain is lager than a certain critical value, e.g., ~13% and ~18% for the  and crystals, respectively, the work hardening rate for both two orientations decreases obviously, but the decrease in work hardening rate is more remarkable for the  crystal rather than the crystal. These phenomena are discussed to be all related to the interactions between moving dislocations and fine Cr-rich precipitates, and the interaction intensity depends strongly on the orientation. Careful observations of slip deformation characteristics and dislocation structures well provide supports for the explanations to the macroscopic compressive plastic flow behavior.