Movable mine refuge chamber is widely used in coal mines for protecting miners from coalmine accident. During a coalmine accident, there will be large heat impact load and stress on the movable mine refuge chamber caused by high temperature and high pressure. Therefore the strength of the movable mine refuge chamber should be carefully designed to meet the safety requirement with the possible lightest weight. Based on analysis of the structure dimensions, material properties, and operating conditions, a finite element model is developed with an emphasis on the effect of the layout and sizes of stiffeners and structural form of the chamber. A comparison of different design schemes is made and the calculation result is given. This work could be helpful for optimization design of China’s movable mine refuge chamber.