Integrated guidance, control and maneuver for anti-vessel missiles against vessel targets was studied. Firstly, the integrated guidance and autopilot model of the yaw plane was formulated, the guidance and control law was designed based on the backstepping method and sliding mode control theory. For the unavailable information of the vessel target, an estimating method was given. Integration of guidance and maneuver was realized based on a new guidance law. Finally, to verify the effectiveness and rightness of the integrated design scheme, the simulation of some anti-vessel missile against maneuvering targets had been made, the simulation results showed that high accuracy performance of guidance and control system can be got.