Although many people discussed the strength and durability of concrete with natural sand in severe environment, few people investigated the mechanics performance of concrete with manufactured-sand under condition of freeze-thaw cycle, at present. Experimental studies on C30 concrete with manufactured-sand were carried out under condition of freeze-thaw cycle, which based on the testing of raw material performance and concrete mix ration, in this paper. Comparative studies on the changing laws of the mass, strength and the relative dynamic elastic modulus of concrete were developed in three cases which were freeze-thaw cycle, freeze-thaw cycle and acid corrosion and freeze-thaw cycle and alkali corrosion. The test results showed that the mass, strength and the relative dynamic elastic modulus of concrete with manufactured-sand decreased evidently with the increasing of times of freeze-thaw cycle. The durability of acid and alkali-resistant of concrete with manufactured-sand was also remarkably weakened due to the action of freeze-thaw cycle. The capability of acid and alkali-resistant of the concrete was decreased with the increasing of times of freeze-thaw cycle and the anti-acid capability was decreased more seriously.