Take a typical cross-section of rockfill embankment slope in Yaan-Luku highway as the research object, reliability analysis is studied under the condition of water table of 840.85m, 851.50m, and loading condition of natural state and horizontal seismic acceleration of 0.2g, respectively. Raw data use Kolmogorov-Smirnov test (K-S test) to determine the distribution type of parametric variation. And the parameters were sampling with Latin hypercube sampling (LHS) method and Monte Carlo (MC) method, respectively, to obtain state function and determine safety factors and reliability indexes. A conclusion is drawn that the times of simulation based on LHS method were less than Monte Carlo method. Also the convergence of failure probability is better than the Monte Carlo method. The safety factor is greater than one and the failure probability has reached to 35.45% in condition of earthquake, which indicating that the instability of rockfill embankment slope is still possible.