The computational model of numerical analysis of a suspended pre-stressed steel reticulated shell subjected to fire load is established with using the software Marc. Based on the model presented here, numerical analysis of thermal response and structural response of the pre-stressed steel structure are computed for the key nodes of the structure. The different location of fire source and different space height are considered for analysis of response temperature, displacements and stresses of the pre-stressed lattice shell. It is shown that the air temperatures was much higher than the response temperatures of the nodes of the lattice shell during a quite period of time after a fire takes place, and the temperature of the cable nodes are also less than the air temperature near the nodes. It is also concluded that displacement of the node right above the inner cable is the maximum among the four nodes as the fire source is located at the position under the middle cable.