The computational model of numerical analysis of a suspended pre-stressed steel reticulated shell subjected to fire load is established with using the software Marc. Based on the model presented here, numerical analysis of thermal response and structural response of the pre-stressed steel structure are computed. The different space height and different rise-span ratio are considered for analysis of response temperature, displacements and stresses of the pre-stressed lattice shell under fire for one fire source. It is also shown that displacement of the node right above the inner cable is the maximum among the four nodes presented here as the fire source is located at the position right below the second-ring cable of the structure. It is concluded that the influence degree of space height of the structure on the fire response of the structure is not great, but rise-span ratio has obvious and great effect on displacements and stresses of the pre-stressed steel structure with large span in fire.