Large-diameter cast-in-situ tubular pile (shorted as LTP) is a new, efficiency and energy saving, environmental protection pile and has been widely put into use in the foundation treatment. Using finite element method (FEM) to analyze and study the behavior of LTP is a very effective research method. This paper adopted the finite element computation software ANSYS 11.0 to conduct a 3-D numerical simulation for the LTP of a typical project. In this paper, it introduced how to realize the finite element model, specifically discussed how to select the appropriate key parameters and proposed an effective method and steps base on experience to determine the key parameters. By calculating, compared the calculated Q-S curve with the measured one and then analyzed the settlement behavior and the inner friction distribution of LTP, it is found that the inner friction only emerge at the bottom of the soil core and the upper part nearly does not have friction. The critical point in depth decreased and the maximum inner friction increased with the increasement of the load. Under the ultimate load, the sphere of influence of LTP decreased rapidly and the inner friction increased significantly.