This paper presents a FBFN-based (Fuzzy Basis Function Networks) adaptive sliding mode control algorithm for nonlinear dynamic systems. Firstly, we designed an perfect control law according to the nominal plant. However, there always exists discrepancy between nominal and actual mode, and the FBFN was applied to approximate the uncertainty. After that, the adaptive law was designed to update the parameters of FBFN to alleviate the approximating errors. Based on the theory of Lyapunov stability, the stability of the adaptive controller was given with a sufficient condition. Simulation example was also given to illustrate the effectiveness of the method.