Along with rapid development of high-speed railway in many countries, recently research on seismic response of high-speed railway bridge under train load has raised much concern among researchers. The whole bridge finite element model is establish to analysis the seismic responses of simply-supported girder railway bridge subjected to high-speed train in this paper, ICE series high speed vehicle is employed as train live load, the vehicle is simulated by moving spring-mass system, The track irregularities can be obtained by Simpack software, the birdge incluing superstructure and substructure is three-dimensional space beam element, the bottom of piers is proposed consolidated. elastic seismic responses of bridge system and elastic-plastic deformation of piers considering different train speeds are calculated. The calculation results indicate that, seismic responses of bridge system are increase with the increase of train speed and earthquake intensity, and the bottom of piers will step into elastic-plasticity stage under high-level earthquake, the plastic hinges occurred within 1.4 meters of bottom of pier. The numerical results can provide some references for design of high-speed railway bridge.