Investigating Fatigue is one the most important factors in designing most mechanical structure. The reason is that, in many cases, the specimens of the structure break down without any warning or signal. Nano and micron’s Coatings are finding more and more applications in industry such as aerospace, automotive, and naval industries. The present article has a purpose. Firstly, it intends to explore the influence of four industrial coatings, namely, hardened chromium, embellished chromium, hardened nickel, and warm galvanizing, all of which have the thickness value at micron levels on fatigue specimens. Moreover, it aims to find the most convenient coating. To achieve these purposes, the abovementioned coatings with the thickness of 13 & 19 were coated on standard specimens who were made of CK45 steel under the same conditions. Then, the S-N curve of each sample was attained empirically according to the standard fatigue testing. Specimens are simulated in the finite element analysis according to experimental conditions and then S-N curve of each sample was attained. Finally, comparing the S-N curves, the most appropriate coating is introduced for the delineated conditions and based fatigue results may be predicted damage of coating.