Anti-aliasing filter is widely used in the field of communication and the information collecting system. Generally, anti-aliasing filter is consisted with a low-pass filter, which possesses rapid roll-off rate. In order to ensure that there will be a very smooth amplitude frequency characteristic, the high order Butterworth low-pass filter is adopted to work as anti-aliasing filter. As we know, to design this kind of high order low-pass filter will involve large amount of manual calculation. In order to reduce the manual calculation job, which is meaningless and reduplicated, in this paper, a MATLAB scripts is proposed to establish a model of computer aided design for anti-aliasing filter. To use this MATLAB scripts, the value of parameter for the filter can be easily got according to the design specification.