MR-TMD is a new type of semi-active control device which combines with Tuned Mass Damper (TMD) and a Magnetorheological (MR) Damper. Taking German ICE3 high-speed railway train through 32meters simply supported box girder bridge for example, a dynamical model of Train-Bridge coupling vibration system is established by considering track irregularities. The relations between the bridge vibration and track irregularities with dampers are studied and the effects of vibration control with TMD and MR-TMD on the bridge are comparatively analyzed. The results show that the effects of track irregularities on vertical displacement of the bridge are relatively small, but on vibration acceleration are relatively large. As the train speed increases, the effects of track irregularities on the vibration acceleration is lager. As the track irregularities increase, the accelerations are greater. MR-TMD is able to inhibit vibration of bridge effectively, and has a wider control range and frequency bandwidth.