A large scale centrifugal shaker is the most effective testing facility for dynamic problems in geotechnical earthquake engineering. There are only two worldwide nowadays, whereas, no one has been established in China. As the most advanced testing facility, almost every aspect in the construction of a large scale centrifugal shaker encounters new challenges. Meanwhile, the facility layout and construction design face many new difficulties. In this paper, the general layout of laboratory and some relevant key technologies in construction are investigated and the scheme of facility general layout is proposed. The composition and variation of total power of centrifuges is analyzed, simultaneously the advantages and limitations of different cooling systems in the operation hall are compared. Also basic requirements and difficulties of foundation design are discussed, which can provide reference and guidance to construction of large scale centrifugal shakers.