Submarine mining is unprecedented in China. XinLi Mining area, affiliated to Sanshandao Gold mine, is the first metal mining carrying out submarine mining exploitation in domestic. No occurrence of uniform settlement, cracking and collapse is the key point during the mining exploitation. According to the mining choosing principle and combining the production practice and relevant experience of Sanshandao Gold mine, the representative schemes are put forward. Two representative test stopes of 63# and 71# are chosen. After the comprehensive comparison and analysis, high-drift back-filling method is adopted to research the safety of submarine mining. Industrial test results show that the high-drift back-filling method has the significant advantages of safety mining, low ore dilution and so on. The mining production ability is improved greatly, obtaining remarkable effect and realizing the key points of higher efficiency and lower loss rate of ores.