This article mainly studied the seismic response of high-rise RC frame and the damping effect with viscoelastic damper. Taking a reinforced concrete frame structure of 12 layers as the research object, six schemes of damper installed were designed and the dynamic characteristics of these schemes were analyzed. The time history response analysis of 3D Tianjin waves was studied for the six schemes under frequent earthquake. The results show that seismic capacity of the structure could be significantly enhanced with dampers under frequent earthquake. Meanwhile, different damper installations also can make the structures have different damping effect.