Due to the increasing of wind disaster, structural wind engineering arouses more and more attention recently, with rapid development on spatial structure and continuous innovation of structural style. The main purpose of structural wind engineering is to calculate the wind pressure coefficients of structure. In this paper, the numerical wind tunnel method (NWTM), based on the Computational Fluid Dynamics (CFD), is applied to study wind load. The wind pressure coefficients of reticulated spherical shell with the 4.6m high wall were first determined, using the NWTM. The results are then compared with the wind tunnel test (WTT) and good agreement is found. The feasibility and reliability of NWTM were then verified. As the second example, NWTM is carried out to predict wind-induced pressure on reticulated spherical shell without wall. Further the distribution behavior of wind pressures on this kind of structures is discussed which could provide professionals the reference for the design of structure.