A pseudo-dynamic test has been finished to a CFST tube structure model. The model with 13 floors and a scale of 1:10 consists of an outer-tube and an inner-tube, the former is a framed-tube supported on CFST frames and the latter is an RC tube. A series of pseudo-dynamic tests on acceleration earthquake waves in four cases (peak acceleration equal to 0.22g, 0.4g, 0.62g and 1.0g) have been fulfilled by taking to the model. Some behavior of model is researched under earthquake, such as displacement time-history cure, force time-history cure and so on. The experiment has illustrated that the CFST tube structure is an outstanding structural style with excellent anti-seismic behavior.