The aseismatic strengthening technique for masonry structure was researched in this paper. The seismic response of a L-type school building with and without isolation system were computed by using software SAP2000. The isolation system were made up of lead rubber bearings or combined Isolation system. The results showed that base-isolated strengthening can reduce not only the translational response but also the torsional response with earthquake. The combined Isolation system was more effetive in decreasing translational response than the lead rubber bearing, but inferior to in decreasing torsion response.