Elasto-plastic analysis of seismic responses of valve hall structures were carried out by using finite element software, and the effect of seismic waves on the seismic responses of the valve hall structures and suspension equipments were studied. Results show that significant torsional responses of the structure can be found under longitudinal and 3D earthquake actions. Under 3D earthquake actions, the seismic responses of the suspension valves are much more significant than those under 1D earthquake actions, the maximum tensile force of the suspenders is about twice of that under 1D action. The seismic responses of the suspension valves under vertical earthquake actions are much stronger than those under horizontal earthquake actions, when suffering strong earthquake actions; the maximum vertical acceleration of the suspension valves is about 4 times of that under horizontal earthquake actions. It is recommended that the effects of 3D earthquake actions on the structure should be considered in seismic response analysis of the valve hall structure.